About 25 results found for searched term "Hydroxysteroid dehydrogenase" (0.129 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2492 | Carbenoxolone Sodium | Hydroxysteroid dehydrogenase |
| Carbenoxolone, a synthetic derivative of glycyrrhetinic acid, is also used as a blocker of the enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD), of pannexon membrane channels (comprising 6 subunits of pannexin) and the related innexon channels. | ||
| M40977 | ALN-HSD | Hydroxysteroid dehydrogenase |
| ALN-HSD is an siRNA and also an inhibitor of 17β-hydroxysteroid dehydrogenase 13 (17β-HSD13), which can be used in studies related to non-alcoholic steatohepatitis (NASH). | ||
| M6034 | Trilostane | Dehydrogenase |
| WIN 24540 | ||
| Trilostane is an inhibitor of 3β-hydroxysteroid dehydrogenase used in the treatment of Cushing’s syndrome. | ||
| M7670 | BMS-770767 | Hydroxysteroid dehydrogenase |
| BMS-770767 is an inhibitor of 11-betahydroxysteroid dehydrogenase type I (11β-HSD1), which is a regulator of glucocorticoid activity and thought to play a possible role in metabolic syndrome. | ||
| M8976 | ASP9521 | Hydroxysteroid dehydrogenase |
| ASP-9521 | ||
| ASP9521 is a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3). | ||
| M14337 | 11beta-Hydroxyprogesterone | Metabolite/Endogenous Metabolite |
| 11β-Hydroxyprogesterone | ||
| 11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM. | ||
| M14664 | BVT-14225 | Hydroxysteroid dehydrogenase |
| BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with an IC50 of 52 nM. | ||
| M17543 | Vibralactone B | Sesquiterpenoids |
| Vibralactone B is a metabolite isolated and cultured from a naturally occurring tambourine bacterium and exhibits weak inhibitory activity (IC50 85.7 μM) against the isoenzyme of 11b-hydroxysteroid dehydrogenase (HSD). | ||
| M17545 | Vibralactone D | Sesquiterpenoids |
| Vibralactone D is a metabolite isolated and cultured from a naturally occurring ascomycete and exhibits weak inhibitory activity (IC50 85.7 μM) against the isoenzyme of 11b-hydroxysteroid dehydrogenase (HSD). | ||
| M18197 | 18alpha-Glycyrrhetinic acid | Proteasome |
| 18α-GA | ||
| 18α-Glycyrrhetinic acid (18α-GA) is a bioactive triterpenoid found in licorice. It is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. It shows selective inhibition of 11-HSD1 (11-hydroxysteroid dehydrogenase 1). | ||
| M20083 | WAY-313218 | Others |
| WAY-313218 is a 11β-hydroxysteroid dehydrogenase type 1 modulator | ||
| M20770 | AKR1C1-IN-1 | Others |
| AKR1C1-IN-1 is a potent and selective inhibitor of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) with Ki of 4 nM, 87 nM, 4.2 μM and 18.2 μM for AKR1C1, AKR1C2, AKR1C3 and AKR1C4, respectively. | ||
| M21098 | INCB13739 | Hydroxysteroid dehydrogenase |
| INCB13739 is an orally effective, selective and tissue-specific 11β-HSD1 (11β-hydroxysteroid dehydrogenase 1) inhibitor with IC50 values of 3.2 nM (11β-HSD1 enzyme) and 1.1 nM (11β-HSD1 PBMC), respectively.INCB13739 can be used in type 2 diabetes mellitus (T2DM) and obesity studies. | ||
| M27656 | AZD 4017 | Hydroxysteroid dehydrogenase |
| AZD 4017 is a potent, selective 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) inhibitor, with an IC50 of 7 nM. | ||
| M27787 | AMG-221 | Hydroxysteroid dehydrogenase |
| AMG-221 is an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with a Ki of 12.8 nM in vitro biochemical scintillation proximity assay (SPA) and an IC50 of 10.1 nM in cell-based assays. AMG-221 can be used for the research of type 2 diabetes. | ||
| M27804 | BI-135585 | Hydroxysteroid dehydrogenase |
| BI-135585 is a potent, selective and orally active 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor with an IC50 of 13 nM. BI-135585 exhibits >1000-fold selectivity over other hydroxysteroid dehydrogenases. BI-135585 can be used for type 2 diabetes research. | ||
| M28211 | SKI2852 | Hydroxysteroid dehydrogenase |
| SKI2852 is a potent, selective and orally active 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC50s of 1.6 nM and 2.9 nM against mHSD1 and hHSD1, respectively. | ||
| M29847 | BI‑3231 | Hydroxysteroid dehydrogenase |
| BI 3231 is a potent and selective hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) inhibitor, with IC50s of 1 and 13 nM for hHSD17B13 and mHSD17B13, respectively. BI 3231 has the potential for the research of nonalcoholic steatohepatitis (NASH) and other liver diseases. | ||
| M30196 | SCH-451659 | Hydroxysteroid dehydrogenase |
| SCH-451659 is an inhibitor of 17β-hydroxysteroid dehydrogenases (17β-HSDs) for cancer research. | ||
| M30757 | ABT-384 | Hydroxysteroid dehydrogenase |
| ABT-384 is a potent, selective 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor. ABT-384 exhibits high affinity (Ki 0.1-2.7 nM) against rodent, monkey, and human 11β-HSD1. ABT-384 blocks regeneration of active cortisol. ABT-384 can be used for the research of Alzheimer’s disease (AD). | ||
| M42273 | Clofutriben | Dehydrogenase |
| Clofutriben (ASP3662) is a 11β-hydroxysteroid dehydrogenase type 1 inhibitor. | ||
| M42274 | HSD17B13-IN-2 | Dehydrogenase |
| HSD17B13-IN-2 is a potent hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) inhibitor. | ||
| M42275 | HSD17B13-IN-3 | Dehydrogenase |
| HSD17B13-IN-3 is a potent hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) inhibitor. | ||
| M42352 | 17β-HSD10-IN-2 | Metabolite/Endogenous Metabolite |
| 17β-HSD10-IN-2 is a benzothiazolylurea-based inhibitor, targeting to 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10), a multifunctional mitochondrial enzyme. | ||
| M42361 | 17β-HSD10-IN-1 | Metabolite/Endogenous Metabolite |
| 17β-HSD10-IN-1 is an orally active inhibitor of 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) with blood-brain permeability. | ||
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